ISO 10298-2018 amd1-2021 PDF

Full title and description

ISO 10298:2018/Amd 1:2021 — Gas cylinders — Gases and gas mixtures — Determination of toxicity for the selection of cylinder valve outlets (PDF). This item is the 2018 third edition of ISO 10298 with Amendment 1 published in 2021, providing updates and additions to the toxicity data and classification methods used when selecting cylinder valve outlets for gases and gas mixtures.

Abstract

ISO 10298:2018 compiles the best available acute inhalation‑toxicity data (LC50 and related values) from the literature to enable classification of gases and gas mixtures by toxicity and to support the selection of appropriate cylinder valve outlets and fittings. Amendment 1 (2021) updates and/or adds entries and editorial corrections to the 2018 publication.

General information

• Status: Published.
• Publication date: ISO 10298:2018 published February 2018; Amendment 1 published October 2021.
• Publisher: International Organization for Standardization (ISO).
• ICS / categories: 71.100.20 (Gases for industrial application / cylinder fittings).
• Edition / version: Edition 3 (2018) with Amendment 1 (2021).
• Number of pages: ISO 10298:2018 — 15 pages; Amendment 1 (2021) — 1 page (combined PDF typically 16 pages when the amendment is supplied as a single document).

Scope

This standard lists validated acute‑toxicity (inhalation) data for single gases and vapours and gives methods for combining data for mixtures so that gases and gas mixtures can be classified for toxicity by inhalation. The classification is intended to inform selection of cylinder valve outlets and other cylinder fittings to reduce risk during handling, transport and use. Amendment 1 updates the data/entries and/or editorial content of the 2018 edition.

Key topics and requirements

• Compilation of acute inhalation‑toxicity data (LC50 basis, preferentially 1‑hour rat data) and rules for choosing best available values.
• Time‑adjustment principles (Haber’s rule and variants) to align data from different exposure durations.
• Toxicity subdivisions/groups used for valve‑outlet selection (examples: non‑toxic, toxic, very toxic based on LC50 thresholds).
• Additive mixture calculation method (using fractions and LC50 values) for classifying gas mixtures without additional animal testing.
• Annexes providing the data‑selection algorithm (data quality, species preference, read‑across rules) and reference tables of LC50 values for numerous substances.

Typical use and users

Used by gas producers, cylinder and valve manufacturers, transport and logistics companies, safety engineers, occupational health professionals, standards committees and regulatory authorities to determine appropriate valve outlets, markings and handling precautions for compressed gas cylinders and gas mixtures. The standard supports decisions about cylinder fittings, safe handling and emergency response planning.

Related standards

ISO 10298:2018/Amd 1:2021 is maintained by ISO/TC 58/SC 2 (Cylinder fittings). A revised edition is in development as ISO/DIS 10298 (the draft replacement). Previous edition ISO 10298:2010 was superseded by the 2018 edition. Users should also consult related cylinder and transport standards from ISO/TC 58 and applicable national regulations for gas transport and cylinder fittings.

Keywords

gas cylinders, gas mixtures, inhalation toxicity, LC50, valve outlets, cylinder fittings, toxicity classification, additive mixture calculation, acute toxicity, ISO 10298.

FAQ

Q: What is this standard?

A: ISO 10298:2018 (with Amendment 1:2021) is an ISO international standard that compiles acute inhalation‑toxicity data and provides methods for classifying gases and gas mixtures to guide selection of cylinder valve outlets and fittings.

Q: What does it cover?

A: It covers selection and presentation of the best available LC50 and related toxicity data, rules for time‑adjustment and read‑across, an additive method to assess mixtures, and annexed reference tables and selection algorithms used to classify gases/mixtures by inhalation toxicity.

Q: Who typically uses it?

A: Gas manufacturers, cylinder and valve manufacturers, transport operators, safety and occupational health professionals, emergency responders and regulatory bodies involved in gas cylinder design, labelling and handling.

Q: Is it current or superseded?

A: The 2018 edition was confirmed in ISO review and remains current; Amendment 1 was published in 2021. A revision (ISO/DIS 10298) is under development and is intended to replace the current edition when published — check ISO/DIS status for the latest progress.

Q: Is it part of a series?

A: ISO 10298 is part of the ISO portfolio on gas cylinders and cylinder fittings maintained by ISO/TC 58/SC 2; it relates to other ISO standards for cylinder design, fittings and transport.

Q: What are the key keywords?

A: LC50, acute inhalation toxicity, gas mixtures, cylinder valve outlets, cylinder fittings, toxicity classification, additive mixture rule.